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In Origin Story, medical historian Howard Markel recounts the two-year period (1858–1860) of Darwin’s writing of On the Origin of Species through its spectacular success and controversy. Simultaneously, Markel delves into the mysterious health symptoms Darwin developed, presenting the first accurate diagnosis of a case that has long fascinated medical historians. The result is a colourful portrait of the man, his friends and enemies and his seminal work, which resonates to this day.