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Sanitation and access to clean water is still an issue for billions. ‘Off-grid Toilets’ is a practical, user-friendly manual to help fight water contamination. Starting as a research project to explore sanitation conditions in Karali, one of the densest informal settlements in Dhaka, Bangladesh, it includes findings and contributions from various collaborators. Detailing the main principles for human waste disinfection, the authors then present a selection of sixteen off-grid toilet systems, how they work, and their advantages and disadvantages. A comprehensive comparison of the proposed solutions is also made to show how different systems can be adapted to respective groups and conditions.